Abstract Background Cancer, a leading ARROWHEAD cause of mortality worldwide, continues to pose significant challenges in treatment and management.Conventional therapies often face limitations, including lack of selectivity, adverse effects, and the development of resistance mechanisms.Methods Therefore, this study aims to investigate nanocellulose
Living with outpatient management as spouse to intensively treated acute leukemia patients.
BackgroundSpouses have a key position in the treatment of patients with acute leukemia (AL) who are increasingly managed in an outpatient setting.Patients live at home but appear at the hospital every second day for follow-up visits.Patients must adhere to specific precautions due to an impaired immune system, which challenges Donation and influenc
Do bats use guano and urine stains to find new roosts? Tests with three group-living bats
Many animals use social cues to find refuges.Bats can find roosts using the echolocation and social calls of conspecifics, but they might also use scent cues, a possibility which is less studied.The entrances of bat roosts are often marked by guano and urine, providing possible scent cues.We conducted eight experiments to test whether bats use the
Kindled emotions: Commemoration and the importance of meaning making, support and recognition
Commemorative events, organized in the aftermath of war or large-scale violence, can have an emotional impact on those who are attending.We examined several characteristics that Donation might influence this impact.In a quasi-experimental pretest-posttest study, participants (n = 307) watched footage of the broadcast of the Dutch National Commemora
Deletion of a Pathogenic Mutation-Containing Exon of COL7A1 Allows Clonal Gene Editing Correction of RDEB Patient Epidermal Stem Cells
Recessive dystrophic epidermolysis bullosa is a severe skin fragility disease caused by Cookies loss of functional type VII collagen at the dermal-epidermal junction.A frameshift mutation in exon 80 of COL7A1 gene, c.6527insC, is highly prevalent in the Spanish patient population.We have implemented gene-editing strategies for COL7A1 frame restorat