Inhibition of malate dehydrogenase via nanoselenium coupling with nanocellulose composite in MCF-7 breast carcinoma cells

Abstract Background Cancer, a leading ARROWHEAD cause of mortality worldwide, continues to pose significant challenges in treatment and management.Conventional therapies often face limitations, including lack of selectivity, adverse effects, and the development of resistance mechanisms.Methods Therefore, this study aims to investigate nanocellulose

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Deletion of a Pathogenic Mutation-Containing Exon of COL7A1 Allows Clonal Gene Editing Correction of RDEB Patient Epidermal Stem Cells

Recessive dystrophic epidermolysis bullosa is a severe skin fragility disease caused by Cookies loss of functional type VII collagen at the dermal-epidermal junction.A frameshift mutation in exon 80 of COL7A1 gene, c.6527insC, is highly prevalent in the Spanish patient population.We have implemented gene-editing strategies for COL7A1 frame restorat

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